Introduction:Traumatic brain injury is considered as the major cause of mortality and hospitalization of about ten million people across the globe. Most of these patients are young and active people who make a lot of disability. Tranexamic acid Drug (TXA) is commonly used to reduce blood loss and need for blood transfusions in surgical cases. This study aimed at investigating the effect of tranexamic acid drug in patients with epidural hematoma.
Methods & Materials/Patients: In a clinical trial study on 100 patients with acute epidural hematoma diagnosed with traumatic brain injury were enrolled. The patients in both groups were matched for age and sex groups. Fifty patients treated with the tranexamic acid drug were compared with 50 patients in the control group. Size of hematoma diameter and hematoma volume between the two groups were studied.
Results: A hundred patients with traumatic brain injury with a mean age of 34.2 ± 7.9 were studied. There were 69% male and 31% female patients. Place of hematoma was 33% in parietal, 39% in the frontal and 28% in temporal region. Hematoma diameter after treatment with tranexamic acid was 3.71 ± 1.8 mm, and in the control group 4.03 ± 1.6 mm, there was no statistically significant difference between the two groups. The volume of hematoma in patients treated with tranexamic acid was 8.04 ± 3.2 cc, and in the control group 10.4 ± 3.7 cc.There was statistically significant diffrenece between the two groups.
Conclusion: According to our study, tranexamic acid drug can be effective on bleeding control in patients with acute epidural hematoma. The role of these drugs in elective surgeries has been proven and in cases of brain trauma could be useful and improving the prognosis of patients.