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The use of local haemostatic agents in neurosurgery is mandatory and one of the most widely used is certainly oxidized regenerated cellulose (SurgicelÔ).

We report on the case of a 54-year-old man previously operated for WHO grade II meningioma, coming back to our attention due to the onset of left side arm weakness one month later. Neuroimaging study showed an extensive lesion on the surgical site with the suspect of intracranial abscess. Intraoperative hystopathological finding suggested the features of a granulomatous foreign body reaction.

This occurrence is very rare following intracranial surgery using oxidized regenerated cellulose as topical haemostatic agent.

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